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nTo turn out just one to two products requires about a
hundred discovery projects or approaches, involving upwards of 7 million
compound tests in early screening assays.
This level of screening
produces about a thousand compounds with some of the criteria we are looking
for. Follow-up molecular design and
sophisticated biological testing narrows the number of development
candidates. Once safety is confirmed
in animal studies, compounds are advanced into human clinical trials where
efficacy, safety and toleration are confirmed.
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