Stanislav Čajavec, Ljiljana Markuš-Cizelj, Maura Ferrari, Vesna Budak, Andrej Cizelj, Alenka Ballarin-Perharić: VACCINE AGAINST CLASSIC PIG PLAGUE
1.  The Invention
	Title : VACCINE AGAINST CLASSIC PIG PLAGUE (PLIVAK-KS/ CHOLERAVAC) The problem the inventor(s) wanted to solve Description. ¸ An original classic pig plague vaccine production process is developed using a lapinised C breed (LC, C=China). Virus suspension is produced by permanent breeding (mitosis) of a permanently infested pig’s kidney cell culture MPK-LC (MPK=minipig kidney) in rotating containers and collection of supernatant with final double harvest. The suspension of vaccinal virus is distributed after microbiological and virological control, stabilizer is added and the suspension is liofilized into products containing 10, 20 or 50 dosages/bottles. In comparison to the lapinised vaccine prepared by infecting rabbits or the vaccine produced in the 90s from the C breed in the MPK cell culture at Instituto Zooprofilattico Sperimentale (Brescia, Italy), the new process results in a much higher yield of vaccinal virus (up to tenfold) at a vaccine protective rate of PD50, which complies to highest world standards (European Pharmacopoeia EP 2005). Genome analisys of VETERINA’s vaccinal virus bred by the new procedure confirmed absolute identicalness with parental lapinised C breed (stored at Instituto Zooprofilattico Sperimentale, Brescia, Italy and > 5% difference compared to the Brescia pathogen breed). Excellent results regarding commercial value and implementation were achieved in the Republic of Croatia in the period 2000-2005 (with full protection of vaccinated animals). Vaccination is stopped in 2005 due to legislative homologization with the EU. The vaccine is sold in the BiH, Macedonia, Philippines and Vietnam, and the process of registration in several other Eurasian countries is under way. Presentation. Fields of application Advantages Stage of development. production item. Documentation available:  ( ) No   (x ) Yes   leaflet, brochure, website,
	Name Stanislav Čajavec^1, Ljiljana Markuš-Cizelj^1, Maura Ferrari^2, Vesna Budak^1, Andrej Cizelj^1, Alenka Ballarin-Perharić^1 Photo. Self introduction. Owner of the invention? (Is it the inventor?)   ( X) No  () Yes ^1VETERINA d.d. ^2 INSTITUTO ZOOPROFILATTICO SPERIMENTALE
3.  Protection
	Patent Status: Patent protected - Priority (date of the very first patent application) Countries where it is in force
4.  Business intention
	Cooperation Selling the new product
5.  Contact
	VETERINA d.d. Svetonedeljska 2, Kalinovica, 10436 Rakov Potok CROATIA www.veterina.com Instituto Zooprofilattico Sperimentale Via A. Bianchi 9 2425251 Brescia Italy